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研究内容

口腔疾患の病態解明・診断治療法の開発応用と口腔組織の機能促進因子の追求を以下の様に行っている。

(1)口腔悪性腫瘍に関する画像診断（PET，MRI，3D-CT）および光学療法
(2)口腔悪性腫瘍に関するシグナル・遺伝子療法（PDE阻害剤，p53）や薬剤耐性克服
(3)顎関節症に対するダイナミックMRI
(4)BMP応用による骨創傷の早期再生，骨芽細胞でのPDEの発現
(5)唾液線の分泌機構
(6)チタンの生体親和性と臨床所見

指導内容

上記研究内容に関連した画像診断，電顕，細胞内シグナル伝達，金属測定に関わる基本的手技につき指導する．

• (1)Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an antitumor agent isolated from Dictyostelium.
  Shimizu K, Murata T, Tagawa T, Takahashi K, Ishikawa R, Abe Y, Hosaka K, Kubohara Y. Cancer Res. 2004 Apr 1;64(7):2568-71.
• (2)Expression and role of phosphodiesterase 5 in human malignant melanoma cell line.
  Murata T, Shimizu K, Watanabe Y, Morita H, Sekida M, Tagawa T.
  Anticancer Res. 2010 Feb;30(2):355-8.
• (3)Synergistic increase in osteosarcoma cell sensitivity to photodynamic therapy with aminolevulinic acid hexyl ester in the presence of hyperthermia.
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  Photomed Laser Surg. 2009 Oct;27(5):791-7.
• (4)Characterization of phosphodiesterase 1 in human malignant melanoma cell lines.
  Shimizu K, Murata T, Watanabe Y, Sato C, Morita H, Tagawa T.
  Anticancer Res. 2009 Apr;29(4):1119-22.
• (5)Bax mRNA therapy using cationic liposomes for human malignant melanoma.
  Okumura K, Nakase M, Inui M, Nakamura S, Watanabe Y, Tagawa T.
  J Gene Med. 2008 Aug;10(8):910-7.
• (6)Subcutaneous administration of lactone form of simvastatin stimulates ectopic osteoinduction by rhBMP-2.
  Sugiyama T, Nakagawa T, Sato C, Fujii T, Mine K, Shimizu K, Murata T, Tagawa T.
  Oral Dis. 2007 Mar;13(2):228-33.
• (7)Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model.
  Yanase S, Nomura J, Matsumura Y, Nagata T, Fujii T, Tagawa T.
  Int J Oncol. 2006 Aug;29(2):365-73.
• (8)Griseofulvin enhances the effect of aminolevulinic acid-based photodynamic therapy in vitro.
  Nomura J, Yanase S, Tokuda T, Matsumura Y, Sekida M, Tagawa T.
  Photomed Laser Surg. 2006 Apr;24(2):186-91.
• (9)Experimental therapy using interferon-gamma and anti-Fas antibody against oral malignant melanoma cells.
  Kamei T, Inui M, Nakase M, Nakamura S, Okumura K, Hiramoto K, Tagawa T.
  Melanoma Res. 2005 Oct;15(5):393-400.
• (10)Expression of cyclic nucleotide phosphodiesterase 3A in isolated rat submandibular acini.
  Shimizu K, Murata T, Hiramoto K, Sugiyama T, Nakagawa T, Manganiello VC, Tagawa T.
  Arch Oral Biol. 2006 Feb;51(2):83-8. Epub 2005 Aug 15.