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主な研究は以下のとおりである。

1. 脳血管内治療の臨床研究
2. 脳血管内治療用デバイスの開発研究
3. 脳動脈瘤の流体解析と４次元画像解析による破裂リスク評価
4. くも膜下出血後合併症の病態解明とその予防法の研究
5. 頚動脈ステント留置術の安全性向上のための研究
6. 神経画像を用いた神経解剖学とその臨床応用
7. 悪性脳腫瘍の集学的治療法の確立
8. 下垂体腫瘍に対する内視鏡手術法の確立
9. てんかん・脳虚血に対する神経保護作用の国際共同研究

• (1)Memorial review celebrating the 50th year of publication of NMC--neuroendovascular therapy.
  Taki W.
  Neurol Med Chir (Tokyo). 2010;50(9):809-23.
• (2)Novel dynamic four-dimensional CT angiography revealing 2-type motions of cerebral arteries.
  Umeda Y, Ishida F, Hamada K, Fukazawa K, Miura Y, Toma N, Suzuki H, Matsushima S, Shimosaka S, Taki W.
  Stroke. 2011 Mar;42(3):815-8.
• (3)Simple immersion of filter devices into an urokinase solution prevents fibrin net formation during carotid artery stenting.
  Hamada K, Matsushima S, Toma N, Totani T, Toda M, Ogawa S, Asakura F, Sakaida H, Iwata H, Taki W.
  J Biomed Mater Res B Appl Biomater. 2010 Oct;95(1):171-6.
• (4)Cerebrospinal fluid tenascin-C increases preceding the development of chronic shunt-dependent hydrocephalus after subarachnoid hemorrhage.
  Suzuki H, Kinoshita N, Imanaka-Yoshida K, Yoshida T, Taki W.
  Stroke. 2008 May;39(5):1610-2.
• (5)Cerebral ischemic lesions detected with diffusion-weighted magnetic resonance imaging after carotid artery stenting: Comparison of several anti-embolic protection devices.
  Taha MM, Maeda M, Sakaida H, Kawaguchi K, Toma N, Yamamoto A, Hirose T, Miura Y, Fujimoto M, Matsushima S, Taki W.
  Neurol Med Chir (Tokyo). 2009 Sep;49(9):386-93.
• (6)Diffusion-weighted MR imaging in carotid angioplasty and stenting with protection by the reversed carotid arterial flow.
  Asakura F, Kawaguchi K, Sakaida H, Toma N, Matsushima S, Kuraishi K, Tanemura H, Miura Y, Maeda M, Taki W.
  AJNR Am J Neuroradiol. 2006 Apr;27(4):753-8.
• (7)Tenascin-C-coated platinum coils for acceleration of organization of cavities and reduction of lumen size in a rat aneurysm model.
  Toma N, Imanaka-Yoshida K, Takeuchi T, Matsushima S, Iwata H, Yoshida T, Taki W.
  J Neurosurg. 2005 Oct;103(4):681-6.
• (8)

  Angioscopic observation during carotid angioplasty with stent placement.
  Tanemura H, Hatazaki S, Asakura F, Kawaguchi K, Kuraishi K, Toma N, Sakaida H, Maeda M, Taki W.
  AJNR Am J Neuroradiol. 2005 Sep;26(8):1943-8.

• (9)Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice.
  Mouri G, Jimenez-Mateos E, Engel T, Dunleavy M, Hatazaki S, Paucard A, Matsushima S, Taki W, Henshall DC.
  Brain Res. 2008 Jun 5;1213:140-51.